Non alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and has emerged as a serious public health challenge. It is mainly in people having insulin resistance and features of metabolic syndrome. Therefore it is most commonly find in type 2 diabetes mellifluous, obesity and dyslipidemia (irregular cholesterol, triglycerides, LDL, HDL, VLDL etc…).
It is characterized by the presence of fat accumulation in the liver in the absence of significant alcohol consumption’s. It is increasingly diagnosed in the India and worldwide. NAFLD can be found in all age groups but prevalence appears to increase with age especially in men.
Features of NAFLD
Majority of patients with NAFLD are asymptomatic (without symptoms) or may have nonspecific symptoms such as fatigue. Most of times it is diagnosed incidentally on imaging or during abdominal surgery for unrelated problem. Thus remain un diagnosed in many patients until in advanced stages. About 2/3rd of patients with NAFLD may have vague complaints of fatigue or malaise or even a sensation of fullness or discomfort in the right abdomen. Central obesity and enlargement of liver are most common reasons of NAFLD. NAFLD is an independent risks factor for cardiovascular disease as well as Diabetes Mellitus.
NAFLD may often be suspected by abnormal liver enzyme levels obtained for non liver- related reasons or conditions. In blood examination of Liver Function Test mild to moderate elevation of SGOT and SGPT are the most common. These are generally increased up to 1.5 to 4 fold the upper limit of normal. You can also read Tips For Diabetes Control
Ultrasound of the liver is the most common used modality for diagnosis NAFLD. Ultrasound is relatively simple, non invasive and cheap. However it may be unable to distinguish different stages of fatty liver. The advance device is Fibro scan to detect changes in the liver texture or stiffness.MRI and CT Scan are other modalities which can diagnose NAFLD.
Liver biopsy is the gold standard for both diagnosis and disease staging.
MANAGEMENT OF NONALCOHOLIC FATTY LIVER DISEASE
Weight loss, in general is associated with improvements in all histologist aspects of NAFLD. Therefore, achieving weight loss through reduction in total calorific intake is likely the most beneficial dietary modification in NAFLD. Diet high in fructose and saturated fats have been implicated in the development of NAFLD. Intake of fast foods(maida products),tinned items, excessive sugar, regular intake of painkillers are some of factors responsible for NAFLD.
Exercise in addition to dietary intervention appears to be most effective foe weight loss. Current obesity guidelines recommend 30 minutes of moderate exercise five times a week to enable weight loss and improve cardiovascular health.However,there is no consensus as to what the ideal duration or intensity is for NAFLD.
Caffeine is considered to be liver protective but its role in NAFLD is unclear. Vitamin E is considered to be benefit in NAFLD. In the absence of any approved medication for this condition, lifestyle changes including dietary restriction, exercise and weight loss remains the mainstay of therapy. For any other assistance with your nearby top doctors click here www.astocare.com